Alina Sharma

Abstract Cancer stem cells (CSCs) drive metastasis and therapy resistance, yet their behaviour within the complex tumour microenvironment remains poorly understood. Here we use a fluorescent reporter that marks CSCs to show that CSCs and their more differentiated progeny display strikingly different population dynamics during metastatic lung colonization in breast cancer models.

1 Introduction Cervical dysplasia is a premalignant condition characterized by abnormal epithelial proliferation and differentiation within the cervical transformation zone, most commonly driven by persistent infection with high-risk human papillomavirus (HPV). High-grade cervical dysplasia (which can extend up to 5 mm below the epithelial surface) carries a substantial risk of progression to invasive cervical cancer if left untreated and therefore requires timely and localized intervention [1].