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Lalage Wakefield

As seen in: Nature, Cell Press
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Articles

Inference of secreted protein signaling activities in intercellular communication

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By Beibei Ru, Lanqi Gong, Emily Yang, Seongyong Park, George Zaki, Kenneth Aldape, Lalage Wakefield, Peng Jiang
| Nature Verified
Abstract The human genome encodes ~1,900 secreted proteins, many of which mediate intercellular communication. Secreted proteins do not act cell-autonomously, limiting systematic approaches to characterize their functions. Here we introduce SecAct (Secreted Activity, https://secact.ccr.cancer.gov), a computational framework that infers the signaling activities of 1,170 human secreted proteins from spatial, single-cell and bulk transcriptomic data.
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Cancer stem cells are hyper-responsive sensors of the tumour microenvironment and regulate metastasis dynamics through YAP/TAZ

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By Binwu Tang, Victoria Gonzalez, ZOYA KHAN, Andrew Gaines, Christine Carney, Daniel Grün, Cristiana M Pineda, Alina Sharma, Dominic P. Esposito, Hualong Yan, Jing Huang, Andy Tran, Michael Kruhlak, Howard Yang, Maxwell Lee, Lalage Wakefield, Jacob Minin, Yuval Raviv, Yu-an Yang, Zachary G. Millman
| Nature Verified
Abstract Cancer stem cells (CSCs) drive metastasis and therapy resistance, yet their behaviour within the complex tumour microenvironment remains poorly understood. Here we use a fluorescent reporter that marks CSCs to show that CSCs and their more differentiated progeny display strikingly different population dynamics during metastatic lung colonization in breast cancer models.
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