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Articles by Allison E. Daly
Stepwise neofunctionalization of the NF-κB family member Rel during vertebrate evolution - Nature Immunology
Abstract Adaptive immunity and the five vertebrate NF-κB family members first emerged in cartilaginous fish, suggesting that NF-κB family divergence helped to facilitate adaptive immunity. One specialized function of the NF-κB Rel protein in macrophages is activation of Il12b, which encodes a key regulator of T cell development.
Examining NFκB Genomic Interactions by ChIP-seq and CUT&Tag
Abstract An understanding of the mechanisms and logic by which transcription factors coordinate gene regulation requires delineation of their genomic interactions at a genome-wide scale. Chromatin immunoprecipitation-sequencing (ChIP-seq) and more recent techniques, including CUT&Tag, typically reveal thousands of genomic interactions by transcription factors, but without insight into their functional roles.
Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50-IκBζ pathway
1,2,3 1Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA; 2Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA; 3Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California 90095, USA Corresponding author: smale{at}mednet.ucla.edu Footnotes Supplemental material is available for this article.
Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50-IκBζ pathway
Abstract The five NF-κB family members and three nuclear IkB proteins play important biological roles,but the mechanisms by which distinct NF-κB and IκB proteins contribute to selective gene transcription remain poorly understood, especially at a genome-scale level. Using nascent transcript RNA-seq, we observed considerable overlap between p50-dependent and IκBζ-dependent genes in Toll-like receptor 4 (TLR4)-activated macrophages.
Stepwise neofunctionalization of the NF-κB family member c-Rel during vertebrate evolution
Abstract Adaptive immunity and the five vertebrate NF-κB/Rel family members first appeared in cartilaginous fish, suggesting that divergence and specialization within the NF-κB family helped facilitate the evolution of adaptive immunity. One specialized function of the NF-κB c-Rel protein in macrophages is the activation of Il12b, which encodes a key regulator of T-cell development.
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins
Abstract Plasma membranes of animal cells are enriched for cholesterol. Cholesterol-dependent cytolysins (CDCs) are pore-forming toxins secreted by bacteria that target membrane cholesterol for their effector function. Phagocytes are essential for clearance of CDC-producing bacteria; however, the mechanisms by which these cells evade the deleterious effects of CDCs are largely unknown.
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