Allyssa L. Daugherty on Muck Rack

Allyssa L. Daugherty

As seen in: Color Research & Application, Cell Press
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Articles

Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils

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By Suhas Sureshchandra, James Henderson, Elizabeth Levendosky, Sankalan Bhattacharyya, Jenna M. Kastenschmidt, Andrew Sorn, Mahina Tabassum Mitul, Timothy Yates, Evien Cheng, Aviv I. Benchorin, Kyle Batucal, Allyssa L. Daugherty, Samuel Murphy, Douglas Trask, Gurpreet Ahuja, Qiu Zhong, Andreas Tiffeau-Mayer, Naresha Saligrama, Lisa E. Wagar, Chandrani Thakur, Annie Moisan
| Cell Press Verified
Keywords T cell receptor repertoire TCR biology human T cells tissue tonsils T follicular helper cells Tfh cells resident memory T cells TRM cells antigen-specific CD8 T cells Introduction T cells are fundamental players in the adaptive immune system and can recognize a remarkable diversity of peptide antigens (Ag) through their T cell receptor (TCR) repertoire.1,2 While blood samples are often used to monitor T cell responses to vaccines and immunotherapies, they represent less than 2% of...
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TGFβ1 orchestrates renal fibrosis following Escherichia coli pyelonephritis

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By Christina Collins, Joy Twentyman, Teri N. Hreha, Allyssa L. Daugherty
| Color Research & Application Verified
Abstract Renal scarring after pyelonephritis is linked to long‐term health risks for hypertension and chronic kidney disease. Androgen exposure increases susceptibility to, and severity of, uropathogenic Escherichia coli (UPEC) pyelonephritis and resultant scarring in both male and female mice, while anti‐androgen therapy is protective against severe urinary tract infection (UTI) in these models.
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