Almke Bader

Abstract Neutrophils, the first cells to arrive at the site of inflammation, are rather short-lived cells and thus have to be constantly replenished. During neutrophil development, vesicle dynamics need to be fine-tuned and impaired vesicle trafficking has been linked to failure in neutrophil maturation. Here, we characterized the role of VPS18 as a central core component of CORVET & HOPS tethering complexes for neutrophil development.

Abstract Aberrant Ras homologous (Rho) GTPase signalling is a major driver of cancer metastasis, and GTPase-activating proteins (GAPs), the negative regulators of RhoGTPases, are considered promising targets for suppressing metastasis, yet drug discovery efforts have remained elusive.

Research Article|Basic Almke Bader, Almke Bader Institute of Cardiovascular Physiology and Pathophysiology, Biomedical Center, LMU Munich, Planegg-Martinsried, 82152 Germany Walter Brendel Center of Experimental Medicine, University Hospital, LMU Munich, Munich, 81377 Germany These authors contributed equally Search for more papers by this author Michael Winkelmann, Michael Winkelmann Institute of Cardiovascular Physiology and Pathophysiology, Biomedical Center, LMU Munich,...