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Articles

Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment

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By WIlliam Green, William Green, Amber Gomez, Alec L. Plotkin, Brandon Pratt, Emily Merritt, Genevieve N. Mullins, Jennifer L Modliszewski, Vasyl Zhabotynsky, Mark Woodcock, Matthew E. Pipkin, Gianpietro Dotti, Jessica E. Thaxton, Yuliya Pylayeva-Gupta, Albert S. Baldwin, JOHN MORRIS, Natalie Stanley, J. Justin Milner, Nancy P. Kren, WIlliam Green, William Green
| Cell Press Verified
Keywords tumor immunology CD8+ T cells tissue-resident cells exhaustion tumor-infiltrating lymphocytes single-cell multiomics pancreatic cancer infection immune memory Get full text access Log in, subscribe or purchase for full access. References 1. Crowl, J.T. ∙ Heeg, M. ∙ Ferry, A. ... Tissue-resident memory CD8(+) T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments Nat. Immunol. 2022; 23:1121-1131 2.
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