Ambrocio Sanchez on Muck Rack

Ambrocio Sanchez

As seen in: Nature
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Articles

Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA - Nature Communications

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By Lavanya Manjunath, Pedro A. Ortega, Ambrocio Sanchez, Sunwoo Oh, Junyi Li, Dana Duong, Elodie Bournique, Bert L. Semler, Dheva Setiaputra
| Nature Verified
Abstract Double-stranded RNAs (dsRNAs) produced during viral infections are recognized by the innate immune sensor protein kinase R (PKR), triggering a host translation shutoff that inhibits viral replication and propagation.
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Cooperative Role of PACT and ADAR1 in Preventing Aberrant PKR Activation by Self-Derived Double-Stranded RNA

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By Lavanya Manjunath, Gisselle Santiago, Pedro A. Ortega, Ambrocio Sanchez
| biorxiv.org
Abstract Double-stranded RNAs (dsRNAs) produced during viral infections are recognized by the innate immune sensor protein kinase R (PKR), triggering a host translation shutoff that inhibits viral replication and propagation.
Open in Who Shared Issue with article?

ATR safeguards replication forks against APOBEC3B-induced toxic PARP1 trapping

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By Pedro A. Ortega, Elodie Bournique, Junyi Li, Ambrocio Sanchez
| biorxiv.org
Abstract ATR is the master safeguard of genomic integrity during DNA replication. Acute inhibition of ATR with ATR inhibitor (ATRi) triggers a surge in origin firing, leading to increased levels of single-stranded DNA (ssDNA) that rapidly deplete all available RPA. This leaves ssDNA unprotected and susceptible to breakage, a phenomenon known as replication catastrophe. However, the mechanism by which unprotected ssDNA breaks remains unclear.
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