Amelia Yin

1 Introduction Iron plays a pivotal role in cellular metabolism, serving as a cofactor for multiple enzymes involved in oxygen transport, oxygen sensing, histone demethylation and energy production, all of which are critical for muscle function and integrity [1]. Iron deficiency is a widespread nutritional disorder, affecting approximately 25% of the global population, with significant health implications.

What is already known? Thermogenic beige adipocytes curb diet-induced obesity by augmenting energy expenditure. The thermogenic gene program in beige adipocytes is tightly controlled by transcriptional and epigenetic mechanisms. What does this study add? A genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) knockout screening identified four repressor genes of beige adipocyte lineage.

Background Localized and systemic hypoxia arise from environmental oxygen reduction, impaired gas exchange, compromised heart function, and localized circulatory defects.