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Amirthaa Suntharalingam on Muck Rack

Amirthaa Suntharalingam

As seen in: Nature, The Journal of Biological Chemistry
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Articles

Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations

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By Shannon Hill, Michelle Kwon, Mackenzie Martin Verified, Amirthaa Suntharalingam
| The Journal of Biological Chemistry Verified
Shannon E. Hill‡, Michelle S. Kwon‡, Mackenzie D. Martin‡, Amirthaa Suntharalingam§, Anthony Hazel¶, Chad A. Dickey§†, James C. Gumbart‡,¶ and Raquel L.
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Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations

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By Shannon Hill, Michelle Kwon, Mackenzie Martin Verified, Amirthaa Suntharalingam
| The Journal of Biological Chemistry Verified
Author contributions: S.E.H., M.S.K., M.D.M., and J.C.G. conceptualization; S.E.H., M.S.K., M.D.M., A.S., A.H., C.A.D., and R.L.L. data curation; S.E.H., C.A.D., J.C.G., and R.L.L. formal analysis; S.E.H., M.S.K., M.D.M., C.A.D., J.C.G., and R.L.L. supervision; S.E.H., M.D.M., C.A.D., J.C.G., and R.L.L. funding acquisition; S.E.H. and M.S.K. validation; S.E.H., M.S.K., M.D.M., A.S., A.H., C.A.D., J.C.G., and R.L.L. investigation; S.E.H., M.S.K., M.D.M., A.H., J.C.G., and R.L.L. methodology;...
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Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

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By Andrew Stothert, Amirthaa Suntharalingam, Xiaolan Tang, Vincent M. Crowley
| Nature Verified
4-Br-BnIm was synthesized as previously described34. A truncated N-terminal domain of Grp94 (NΔ41, residues 69–337; residues 287–327 replaced by GGGG) was expressed and purified as previously described34. Crystals of apo-NΔ41 were grown by the hanging drop method with equilibration of the protein (at 15 mg/mL) against a reservoir solution comprised of 35% PEG400, 100 mM Tris at pH 7.5, and 80 mM MgCl .
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