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Amitis Akbari on Muck Rack

Amitis Akbari

As seen in: Frontiers
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Articles

Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance

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By Pedram Shafiei-Jahani, Xin Li, Ryan Carlisle, Carolyn Goh, Vanessa Holland, Omid Akbari, Amitis Akbari, Emily Haniff, Melissa Ziprick
| Frontiers
Abstract Autoimmune and immune-mediated alopecias demonstrate how a site-specific failure of immune privilege can produce reversible or irreversible hair loss. In alopecia areata (AA), cytotoxic injury is concentrated at the anagen bulb but preserves the stem cell pool, permitting regrowth following immune suppression. Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) feature a spectrum of chronic interface dermatitis that destroys the stem cell niche, leading to permanent fibrosis.
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