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Omid Akbari on Muck Rack

Omid Akbari

As seen in: Color Research & Application, Nature, Wiley Online Library, Yahoo News New Zealand, ScienceDirect, Frontiers, MDPI, The BMJ, The Conversation, ACS Publications and
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Articles

Tim-3 agonist restrains ILC2 function and attenuates airway hyperreactivity via NLK pathway

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By Yoshihiro Sakano, Kei Sakano, Kota Kokubo, Benjamin P. Hurrell, Stephen Shen, Xin Li Verified, Jafar Cain, Vijay K. Kuchroo, Omid Akbari
| Nature Verified
Abstract Allergic asthma is promoted by type 2 inflammation involving cytokines such as IL-4, IL-5, and IL-13, with group 2 innate lymphoid cells (ILC2s) playing a key pathogenic role. Here, we identify T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) as a negative regulator of ILC2 function.
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Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance

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By Pedram Shafiei-Jahani, Xin Li, Ryan Carlisle, Carolyn Goh, Vanessa Holland, Omid Akbari, Amitis Akbari, Emily Haniff, Melissa Ziprick
| Frontiers
Abstract Autoimmune and immune-mediated alopecias demonstrate how a site-specific failure of immune privilege can produce reversible or irreversible hair loss. In alopecia areata (AA), cytotoxic injury is concentrated at the anagen bulb but preserves the stem cell pool, permitting regrowth following immune suppression. Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) feature a spectrum of chronic interface dermatitis that destroys the stem cell niche, leading to permanent fibrosis.
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PepFoundry: A Pipeline for Building Machine-Learning Ready Representations of Nonstandard Peptides Containing Cycles, Non-natural Residues, Polymer Units, and More

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By Daniel Otero, Omid Akbari, Camille Bilodeau, Aneesh Mandapati
| ACS Publications
1. Introduction Click to copy section linkSection link copied! Peptides with synthetic modifications, such as noncanonical amino acids (NCAAs), backbone modifications, cyclic structures, and polymer units, have become prevalent in peptide-based drug design, fueling a market worth over $40 billion (1) and allowing access to molecules and materials with a range of useful properties and behaviors.
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