Amrit Bagchi

Abstract Most wounds form scars without hair follicles. However, in the wound-induced hair neogenesis (WIHN) model of skin regeneration, wounds regenerate hair follicles if tissue rigidity is optimal. Although WIHN depends on Wnt signaling, whether Wnt performs a mechanoregulatory role that contributes to regeneration remains uncharacterized. Here, we demonstrate that Wnt signaling affects mechanosensitivity at both cellular and tissue levels to drive WIHN.

Loading metrics Open Access Peer-reviewed Research Article Citation: Bagchi A, Sarker B, Zhang J, Foston M, Pathak A (2025) Fast yet force-effective mode of supracellular collective cell migration due to extracellular force transmission. PLoS Comput Biol 21(1): e1012664. https://doi.org/10.1371/journal.pcbi.1012664 Editor: Philip K.

Abstract Cell collectives, like other motile entities, generate and use forces to move forward. Here, we ask whether environmental configurations alter this proportional force-speed relationship, since aligned extracellular matrix fibers are known to cause directed migration. We show that aligned fibers serve as active conduits for spatial propagation of cellular mechanotransduction through matrix exoskeleton, leading to efficient directed collective cell migration.