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Amritaj Patra on Muck Rack

Amritaj Patra

As seen in: The Journal of Biological Chemistry
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Articles

Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι

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By Jeong-Yun Choi, Amritaj Patra, Mina Yeom, Young-Sam Lee
| The Journal of Biological Chemistry Verified
DNA polymerase (pol) ι is a Y-family polymerase involved in translesion synthesis, exhibiting higher catalytic activity with Mn2+ than Mg2+. The human germline R96G variant impairs both Mn2+-dependent and Mg2+-dependent activities of pol ι, whereas the Δ1–25 variant selectively enhances its Mg2+-dependent activity. We analyzed pre-steady-state kinetic and structural effects of these two metal ions and genetic variations on pol ι using pol ι core (residues 1–445) proteins.
Open in Who Shared Issue with article?

Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι

|
By Jeong-Yun Choi, Amritaj Patra, Mina Yeom, Young-Sam Lee
| The Journal of Biological Chemistry Verified
DNA polymerase (pol) ι is a Y-family polymerase involved in translesion synthesis, exhibiting higher catalytic activity with Mn2+ than Mg2+. The human germline R96G variant impairs both Mn2+- and Mg2+-dependent activities of pol ι, while the Δ1-25 variant selectively enhances its Mg2+-dependent activity. We analyzed pre-steady-state kinetic and structural effects of these two metal ions and genetic variations on pol ι using pol ι core (residues 1−445) proteins.
Open in Who Shared Issue with article?
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