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Ana Vasquez-Ibarra on Muck Rack

Ana Vasquez-Ibarra

As seen in: Nature
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Articles

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells

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By Hyuncheol Jung, Pascal Devant, Mineto Ota, Emma Dann, Ronghui Zhu, Chandrima Modak, Jennifer Hamilton, Zachary Steinhart, Wayne Ngo, Luis Sandoval, Jae Hyung Jung, Jae Lee, Da Xu, Meirui An, Esha Urs, Peixin Chen, Vincent Allain, Takuya Tada, Luke A Gilbert, Brian Shy, Jonathan Pritchard, James Nunez, James Nuñez, Nathaniel Landau, David R. Liu, Justin Eyquem, Jennifer Doudna, Alexander Marson, Julia Carnevale, Carter Ching, Ana Vasquez-Ibarra
| Nature Verified
Abstract Primary human myeloid cells hold promise for immunotherapies, yet efficient, scalable technologies for engineering and screening in these cells remain limited. Here we present a virus-like particle (VLP)-based toolkit that delivers diverse CRISPR editing modalities to human monocytes, macrophages and dendritic cells with high efficiency while preserving viability and innate immune responsiveness.
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