231 formalin-fixed paraffin-embedded specimens of OSCC resections/biopsies were obtained from the University of Iowa Hospital and Clinics and the College of Dentistry (University of Iowa) between 2004–2014. Tissue slides were reviewed to confirm the original diagnosis, and clinicopathological characteristics were collected, including age, sex, smoking history, tumor location, T-stage, N-stage, tumor differentiation, PNI, LVI, and bone invasion.