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Anders Handrup Kverneland

As seen in: BMJ Oncology
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Articles

Benchmarking Plasma Proteomics Workflows and Their Correlation to Clinical Routine Protein Assays Click to copy article link Article link copied!

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By Anders Handrup Kverneland, Ole Østergaard, Luisa Schmidt
| dx.doi.org
Introduction Click to copy section linkSection link copied! Peripheral blood is the single most important body fluid for measuring biomarkers in clinical practice. It is a rich source of systemic biological information and is firmly implemented into daily clinical practice, given its relative ease of accessibility. For measurements of proteins and other molecules, the noncellular component of the blood is isolated through centrifugation into either serum or plasma.
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Identification of protein biomarker candidates associated with organ-specific immune-related toxicity and response to management by plasma proteomics

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By Ole Østergaard, Inge Mansfield Noringriis, Anders Handrup Kverneland, Joel Emanuel Sohlin
| BMJ Oncology Verified
Bloodborne biomarkers are routinely used to diagnose immune-related adverse events (irAEs) in a tissue-specific approach, but for many tissues, no biomarkers are available. Management is, as first line, a one-size-fits-all with corticosteroids, while second line is tissue-specific based on experiences in autoimmune disorders. Patient stratification for management is currently not performed.
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