Andra C Dumitru

Abstract Titin, the elastic protein scaffold of muscle sarcomeres, has multifunctional roles in mechanosignalling and is implicated in muscle disease. However, the consequences of disrupting titin’s mechanical function in vivo remain incompletely understood.

Correction to: Nature https://doi.org/10.1038/s41586-025-08741-5 Published online 19 March 2025 In the version of the article initially published, in the “Mice” paragraph of the Methods, the text “The mouse sequence for the CNA35-mCherry cassette was obtained from Dr. Rinkevich at Helmholtz Zentrum Munchen” was missing and has now been added.

Abstract Defence from environmental threats is provided by physical barriers that confer mechanical protection and prevent the entry of microorganisms1. If microorganisms overcome those barriers, however, innate immune cells use toxic chemicals to kill the invading cells2,3. Here we examine immune diversity across tissues and identify a population of neutrophils in the skin that expresses a broad repertoire of proteins and enzymes needed to build the extracellular matrix.