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Lai Guan Ng

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Articles

Cancer stem cells orchestrate immune evasion through extracellular vesicle-mediated non-canonical signaling pathways

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By Guangjian Fan, Juan Jin, Jie Wang, Jingxuan Xu, Weiyu Ge, Suling Liu, Lei Tang Verified, Wumaier Reziya, Xiaoyi Yang, Junjian Li, Lai Guan Ng, Lijun Di, Yuanting Zheng, Shizhuo Chen, Yan Zhang, Xin Wang, Dong Gao, Xindong Liu, Haoyu Sun, Yinbing Liu, Ting Li, Yiqun Cao, Zhonghua Tao, Wenting Liu, Hongxia wang
| Cell Press Verified
Keywords immunosuppression cancer stem cells Tregs triple-negative breast cancer extracellular vesicles Tetraspanin-8 combined immunotherapy Get full text access Log in, subscribe or purchase for full access. References 1. Liu, X. ∙ Li, J. ∙ Cadilha, B.L. ... Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis Sci. Adv. 2019; 5:eaav4275 2. Yin, Z.Q. ∙ Liu, J.J. ∙ Xu, Y.C. ...
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Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells

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By Ying Chen, Junjie Lei, Pradeep Singh Gautam, Pongsatorn Horcharoensuk, Katja G. Weinacht, Nicholas R. J. Gascoigne, Jinmiao Chen, Ching Kit Chen, Qingfeng Chen, Qi-Jing Li, Lai Guan Ng, Yuin-Han Loh, Uma S. Kamaraj, Czaryna K. M. Clemente
| Nature Verified
Abstract The thymus is the primary site for T cell maturation. While transcriptional profiling of human thymi has been reported, a high-resolution spatial atlas is needed. Here we use Stereo-seq spatial transcriptomics to generate a spatial atlas of the human fetal (13, 14, 17 or 18 weeks post-conception) and pediatric (7 weeks, and 2, 5 or 6 years old) thymi.
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Temporal and spatial atlas of eosinophil specialization across tissues - Nature Immunology

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By Jiaqian Xu, Zhaoyuan Liu, Liming Lu, Lai Guan Ng, Bing Su, Florent Ginhoux, Ziyi Li, Lianfu Wu
| Nature Verified
Abstract Eosinophils are multifunctional granulocytes involved in immune regulation, metabolism and tissue repair; however, the extent of their heterogeneity across tissues and the principles governing their specialization are not well defined. Here, we present a single-cell transcriptomic and proteomic atlas of mouse eosinophils spanning immune, barrier and metabolic sites.
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