André Godoy

Å ångström BLASTp Basic Local Alignment Search Tool for proteins CAZy Carbohydrate-Active enZymes database CBM carbohydrate-binding module CC correlation coefficient cryo-EM cryo-electron microscopy CTF contrast transfer function DALI Distance-matrix ALIgnment DMSO dimethyl sulfoxide EcXyl43 Enterobacter cloacae glycoside hydrolase family 43 β-xylosidase EMDB Electron Microscopy Data Bank EMPIAR Electron Microscopy Public Image Archive FSC Fourier shell correlation GH glycoside hydrolase GH43...

Abstract The Zika viral protease NS2B-NS3 is essential for the cleavage of viral polyprotein precursor into individual structural and non-structural (NS) proteins and is therefore an attractive drug target. Generation of a robust crystal system of co-expressed NS2B-NS3 protease has enabled us to perform a crystallographic fragment screening campaign with 1076 fragments.