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Articles by Andreas Boldt
MyCARdiac score: integrating cardiac imaging and biomarkers to predict outcomes in RRMM patients receiving cilta-cel - Leukemia
To the Editor Chimeric antigen receptor (CAR) T-cell therapy has transformed treatment for relapsed and refractory multiple myeloma (RRMM), but its wider use has renewed attention to off-target toxicities.
A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma
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Results We recruited a real-world cohort of 61 RRMM patients treated with BCMA-directed CAR T cells at our center. Samples of 57 patients were available for single-cell multi-omics profiling: A total of 135 peripheral blood mononuclear cell (PBMC) samples at 3 different time points were collected for single cell RNA, B cell receptor (BCR), TCR and surface protein profiling.
By Michael Rade, David Fandrei, Markus Kreuz, Sabine Seiffert, Anja Grahnert, Maik Friedrich, Thomas C. Wiemers, Patrick Born, Luise Fischer, Heike Weidner, Lorenz C. Hofbauer, Ronny Baber, Song Wang, Enrica Bach, Sandra Hoffmann, Jonathan Scolnick, Mirco Friedrich, Farid Keramati, Peter Brazda, Zsolt Sebestyen, Jürgen Kuball, Miriam Alb, Lukas Scheller, Michael Hudecek, Hermann Einsele, Klaus H. Metzeler, Marco Herling, Carmen Diana Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Andreas Boldt, Ulrike Kohl, Uwe Platzbecker, Vladan Vucinic, Kristin Reiche, Maximilian Merz
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Cell Press
Verified
Dichotomous STAT5 and STAT6 Activation in T Cells Reflects Cytokine Shifts Between Blood and Skin in Atopic Dermatitis
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
Clinical response of CARD14‐associated papulosquamous eruption to an anti‐interleukin‐17A antibody
Abstract Here we present another family with CARD14-associated papulosquamous eruption, which is characterized by mutations in CARD14 and skin lesions resembling psoriasis and pityriasis rubra pilaris. We show beneficial therapeutic response to anti-IL17A treatment in one patient and performed immunomonitoring of our patient, exhibiting enhanced pSTAT3 levels in T cells before treatment, which normalized after treatment.
Flow cytometric measurement of STAT1 and STAT3 phosphorylation in CD4+ and CD8+ T cells - Clinical applications in PID diagnostics
Publication HistoryPublished online: June 07, 2017Accepted: May 10, 2017; Received in revised form: May 8, 2017; Received: January 2, 2017;
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