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Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
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Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome
This article describes one method of oleic acid-induced lung injury as a model for studying various aspects of severe ARDS. There are also other protocols with different emulsions, different injection sites, and different temperatures of the emulsion23,24,25,26,27,28,29. Our method offers a reproducible and stable deterioration in lung function.
Lung injury does not aggravate mechanical ventilation-induced early cerebral inflammation or apoptosis in an animal model
The acute respiratory distress syndrome is not only associated with a high mortality, but also goes along with cognitive impairment in survivors. The cause for this cognitive impairment is still not clear. One possible mechanism could be cerebral inflammation as result of a “lung-brain-crosstalk”. Even mechanical ventilation itself can induce cerebral inflammation.
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