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Articles by Andreas Husch
An intrinsic cytoskeletal oscillator establishes neuronal polarity
Abstract Neurons acquire polarity by specifying one neurite as the axon, whereas the others become dendrites. But how this fundamental asymmetry is established remains unclear1. Neuronal polarization has been thought to rely primarily on growth cones that sense external cues2. Here we show that growth cones alone do not direct this process and that the soma acts as a central organizer of neuronal polarization.
[2512.16685] Few-Shot Fingerprinting Subject Re-Identification in 3D-MRI and 2D-X-Ray
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Towards automatic home-based sleep apnea estimation using deep learning - npj Digital Medicine
Abstract Apnea and hypopnea are common sleep disorders characterized by the obstruction of the airways. Polysomnography (PSG) is a sleep study typically used to compute the Apnea-Hypopnea Index (AHI), the number of times a person has apnea or certain types of hypopnea per hour of sleep, and diagnose the severity of the sleep disorder. Early detection and treatment of apnea can significantly reduce morbidity and mortality.
An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury
Highlights • Axon growth-competent adult neurons downregulate critical components of the synapse • Pharmacogenetic reduction of neuronal excitability stimulates axon regeneration • The presynaptic active zone proteins Munc13 and RIM suppress axon growth • Systemic Baclofen treatment promotes regeneration after adult spinal cord injury Summary Axons in the adult mammalian central nervous system fail to regenerate after spinal cord injury.
Dynamical SPQEIR model assesses the effectiveness of non-pharmaceutical interventions against COVID-19 epidemic outbreaks
Loading metrics Open Access Peer-reviewed Research Article Daniele Proverbio , Françoise Kemp, Stefano Magni, Andreas Husch, Atte Aalto, Laurent Mombaerts, Alexander Skupin, Jorge Gonçalves, Jose Ameijeiras-Alonso, Christophe Ley Daniele Proverbio, Françoise Kemp, Stefano Magni, Andreas Husch, Atte Aalto, Laurent Mombaerts, Alexander Skupin, Jorge Gonçalves, Jose Ameijeiras-Alonso, Christophe Ley Published: May 21, 2021 https://doi.org/10.1371/journal.pone.0252019 Figures Abstract Against the...
Impressive weight gain after deep brain stimulation of nucleus accumbens in treatment-resistant bulimic anorexia nervosa
Impressive weight gain after deep brain stimulation of nucleus accumbens in treatment-resistant bulimic anorexia nervosa http://orcid.org/0000-0002-5424-1198Isabel Fernandes Arroteia1, Andreas Husch2, Mehri Baniasadi2 and Frank Hertel1,2 1Department of Neurosurgery, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg 2Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg Correspondence to Dr Isabel Fernandes Arroteia;...
RhoA Controls Axon Extension Independent of Specification in the Developing Brain
Highlights • RhoA restrains axon initiation and growth independent of specification • Myosin II is the physiological target of RhoA during axon growth • RhoA/myosin-II-dependent actin arcs restrict microtubule advance in the growth cone • RhoA instructs the duration of growth and pause phases in developing axons Summary The specification of an axon and its subsequent outgrowth are key steps during neuronal polarization, a prerequisite to wire the brain.
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