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A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Groden M, Moessinger HM, Schaffran B, DeFelipe J, Benavides-Piccione R, Cuntz H, et al. (2024) A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites. PLoS Comput Biol 20(2): e1011267.
A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites
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An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury
Highlights • Axon growth-competent adult neurons downregulate critical components of the synapse • Pharmacogenetic reduction of neuronal excitability stimulates axon regeneration • The presynaptic active zone proteins Munc13 and RIM suppress axon growth • Systemic Baclofen treatment promotes regeneration after adult spinal cord injury Summary Axons in the adult mammalian central nervous system fail to regenerate after spinal cord injury.
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