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Andrée E Gravel on Muck Rack

Andrée E Gravel

As seen in: The Journal of Biological Chemistry
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Articles

Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation

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By Chai-Ann Ng, Andrée E Gravel, Matthew Perry, Alexandre A Arnold
| The Journal of Biological Chemistry Verified
Slow deactivation of Kv11.1 channels is critical for its function in the heart. The S4-S5 linker, which joins the voltage sensor and pore domains, plays a critical role in this slow deactivation gating. Here, we use NMR spectroscopy to identify the membrane-bound surface of the S4S5 linker, and we show that two highly conserved tyrosine residues within the KCNH subfamily of channels are membrane-associated.
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Tyrosine residues from the S4-S5 linker of Kv11.1 channels are critical for slow deactivation

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By Matthew Perry, Chai-Ann Ng, Andrée E Gravel, Alexandre A Arnold, Isabelle Marcotte
| The Journal of Biological Chemistry Verified
Author contributions: JIV conceived and coordinated the study. CAN, AEG, IM and JIV wrote the paper. CAN designed, performed and analyzed the experiments shown in Figures 1, 3, 4, 5 and 6. AEG and IM designed, performed and analyzed the experiments shown in Figure 2. MDP and AAA assisted with the designed of experiments and acquisition of data. All authors contributed to the preparation of the figures and approved the final version of the manuscript.
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