Andrew Barbour
Menlo Park
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Emergent Radiotherapy for Brain and Leptomeningeal Metastases: A Narrative Review
Publication Date 11-1-2023 Journal Annals of Palliative Medicine Abstract Background and objective: As novel systemic therapies allow patients to live longer with cancer, the risk of developing central nervous system (CNS) metastases increases and providers will more frequently encounter emergent presentation of brain metastases (BM) and leptomeningeal metastases (LM). Management of these metastases requires appropriate work-up and well-coordinated multidisciplinary care.
The neoantigen and associated tumour microenvironment in long-term survivors with oesophageal adenocarcinoma
Abstract Background: Oesophageal adenocarcinoma (OAC) is a highly mutated cancer with poor survival. While outcomes are improving, long-term survival remains elusive for the majority of patients. Immunotherapy in combination with chemotherapy has shown benefit but is effective in only a subset of patients, highlighting the lack of reliable genomic biomarkers for response and survival. Effective anti-tumour immune responses, including those targeting neoantigens, are critical for durable outcomes.
Sharp structural variability of the Gorda slab imaged by a fiber array
Abstract Structural variability at the subduction interface imposes stress and strength heterogeneity that affects the behavior of megathrust earthquakes. Characterizing this variability can be challenging because the slab interface is often deep and seismically quiet. Seismic wavefields from intraslab earthquakes can contain high-frequency phase conversions from the megathrust fault that are delayed and distorted by interface topography and velocity heterogeneity.
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