Rituparna Bhatt on Muck Rack

Rituparna Bhatt

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Articles

Using targeted therapy to promote a pro-inflammatory tumour microenvironment and anti-tumour immune response in high grade serous ovarian cancer

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By Zhen Zeng, Anastasia Gandini, Martina Proctor, Shivam Vora, Thomas Walsh, Sherry Wu, Jermaine I. Coward, Snehlata Kumari, Nikolas K. Haass, James Wells, Janet R. Hardy, Yaowu He, John Hooper Verified, Brian Gabrielli, Rituparna Bhatt, Nicole-Lisa Li-Ann Goh, Kaltin Ferguson, Lewis Perrin, Gwo-Yaw Ho, Jazmina L. Gonzalez Cruz
| Nature Verified
Abstract High-grade serous ovarian cancer (HGSOC) is characterized by elevated replication stress and an immunosuppressive microenvironment. A synergistic combination of checkpoint kinase 1 inhibitor (CHK1i) with low-dose hydroxyurea (LDHU) promotes a unique ATR-independent moderate replication stress response with potent anti-tumour effects.
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