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Andrew Caravello

As seen in: Frontiers in Immunology, Medscape, KevinMD.com
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Articles by Andrew Caravello

Chronic inflammation and immune aging may share mechanisms

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By Andrew Caravello
| KevinMD.com
For more than two decades, I have practiced emergency medicine. The job trains you to recognize patterns quickly because sometimes the pattern is the difference between sending someone home and recognizing a catastrophe that is still assembling itself. A heart attack arrives after years of vascular disease and suddenly becomes an emergency. A stroke may represent decades of biology revealed in minutes.
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A proposed convergent molecular chain linking senescence, cancer, and chronic infection to a correctable failure of dendritic cell instruction

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By Andrew Caravello, Andrew Blidy
| Frontiers in Immunology
Abstract Background: Three convergent phenomena in biomedical research have lacked a unified mechanistic explanation: the dendritic cell dysfunction of aging, the immune evasion of cancer, and the tolerogenic bias of chronic infection. Each is characterized by failure of type 1 conventional dendritic cell (cDC1) instruction and loss of its bioactive IL-12p70 output. Hypothesis: We propose that these three phenomena share a single molecular cause: sustained silencing of IRF8 by a four-step chain.
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The Biological Reboot: How the Alpha-Type-1 Polarized Dendritic Cell Restores Bidirectional Immune Instruction

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By Andrew Caravello, Andrew Blidy
| Preprints.org
You are already at the latest version Background: The dendritic cell initiates and directs antigen-specific immunity. Three Nobel Prizes frame the system it controls: Steinman (2011) recognized the dendritic cell as the conductor of adaptive immunity; Allison and Honjo (2018) recognized CTLA-4 and PD-1 as checkpoints restraining effector responses; Sakaguchi, Brunkow, and Ramsdell (2025) recognized that Foxp3-positive regulatory T cells maintain peripheral tolerance.
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An Adopted 43-Year-Old With Bad Breath, Dyspnea, Dysphagia

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By James Espinosa, Alexander B. Norinsky, Andrew Caravello
| Medscape Verified
close Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Log out Cancel Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills using the following patient scenario and corresponding questions.
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