Andrew David Miranker on Muck Rack

Andrew David Miranker

As seen in: Chemistry World
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Articles

PLIGHT: A tool to assess privacy risk by inferring identifying characteristics from sparse, noisy genotypes

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By Prashant Emani, Gamze Gürsoy, Andrew David Miranker, Mark Gerstein
| biorxiv.org
Abstract The leakage of identifying information in genetic and omics data has been established in many studies, with single nucleotide polymorphisms (SNPs) shown to carry a strong risk of reidentification for individuals and their genetic relatives.
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Foldamer scaffolds suggest distinct structures are associated with alternative gains-of-function in a preamyloid toxin

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By Sunil Kumar, Melissa Birol, Andrew David Miranker
| Chemistry World Verified
An oligoquinoline foldamer library was synthesized and screened for agonism of lipid bilayer catalysed assembly of islet amyloid polypeptide (IAPP). One tetraquinoline, ADM 116, showed exceptional potency not only in this assay, but also in follow-up assays measuring lipid bilayer integrity and rescue of insulin secreting cells from the toxic effects of IAPP.
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