Loading metrics Open Access Peer-reviewed Research Article Citation: Friedson A, Humphreys A, Cha J (2026) Measuring representation in clinical trials: Simulations demonstrating how current methods fail in the context of precision medicine. PLoS One 21(3): e0342711. https://doi.org/10.1371/journal.pone.0342711 Editor: Ebenezer Wiafe, University of Health and Allied Sciences, GHANA Received: June 10, 2025; Accepted: January 27, 2026; Published: March 10, 2026 Copyright: © 2026 Friedson et al.