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Andreyah L. Pope on Muck Rack

Andreyah L. Pope

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Articles

A Conserved Proline Hinge Mediates Helix Dynamics and Activation of Rhodopsin

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By Stony Brook, Kieron South, Andreyah L. Pope, Omar B. Sanchez-Reyes
| Cell Press Verified
Highlights • Rhodopsin activation results in unraveling of the H6 backbone within the CWxP motif • Tyr3017.48 appears to mimic the negative allosteric sodium ion found in other GPCRs • The A295V7.42 constitutively active CSNB mutation unravels the H6 backbone • Switch 2 is likely the primary activation switch in rhodopsin and other class A GPCRs Summary Despite high-resolution crystal structures of both inactive and active G protein-coupled receptors (GPCRs), it is still not known how ligands...
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