Andy Pike
United Kingdom
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Articles by Andy Pike
Foundational economy, geography and ‘left behind places’
ABSTRACT Foundational economy (FE) is part of the proliferation of alternative approaches following the Global Financial Crisis in 2008. FE is an influential agenda in urban and regional studies, but its geographical dimensions are under-developed. This paper explains and demonstrates the value and challenges of a more geographically grounded and sensitive approach to FE.
A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader
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Abstract Immunomodulatory imide drugs (IMiDs) like lenalidomide and pomalidomide are effective in treating multiple myeloma (MM) but pose hematotoxicity risks by degrading neosubstrates Ikaros (IKZF1) and Aiolos (IKZF3). When these IMiD scaffolds are integrated into proteolysis targeting chimeras (PROTACs), they can inadvertently lead to the degradation of these neosubstrates alongside the intended protein of interest (POI), raising safety concerns.
By Monica C. Rodrigo-Brenni, Ghaith M. Hamza, Natacha Bohin, Tomas Adomavicius, Angelo Andres, Ulf Börjesson, Gavin W. Collie, Frederik Eisele, Ning Gao, Christoph Grebner, Frida Gustafsson, Andreas Hock, Praveen Kumar, Xin Li Verified, Ruth MacDonald, Katja Madeyski-Bengtson, Eric Stefan Miele, Philip Nevin, Jeroen Overman, Fiona Pachl, Claudio Pathe, Matthew Perry, Christopher Phillips, Andy Pike, Ian Purvis, Timothy Rasmusson, Sophie Regan, Linda Reilly, Jonathan Rose, Jingwen Wang, Xiang Zhai, Iacovos N. Michaelides, Kevin Moreau, Jasper C. Komen, Stefan Blaho, Gian Marco De Donatis, Andrea Gohlke, Cecilia Kankkonen, Emilyanne Leonard, R. Ian Storer
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Nature
Verified
Lessons learned in linking PROTACs from discovery to the clinic - Nature Reviews Chemistry
Abstract Targeted protein degradation has the potential to deliver greater efficacy than conventional receptor antagonists or enzyme inhibitors and address previously undruggable targets. This has driven a recent surge of interest in protein degradation modalities. Bifunctional degraders, specifically proteolysis targeting chimeras (PROTACs), have become a key modality in the protein degrader space, despite the physicochemical challenges they present in achieving oral bioavailability.
Fixing councils' financial distress
Local authorities estimate their budget shortfalls will reach £9.3bn by 2026-27, adding another bleak forecast to existing reports of their financial distress. Crisis in local government is nothing new. But our understanding of the geography, institutional and political dimensions of the contemporary funding gaps has been limited. Drawing from the medium-term financial strategies published by each of the 317 local authorities across England, Mapping the Gaps shows how geography matters.
A long and winding road
Fixing regional governance in North East England Antecedents “The time may come when this Northern Province will find in a regional council the solution of some of those social problems which have baffled our statesmanship during recent years.” Various proposals for regional government were aired in the post-war period, The search for a fix for the problem of regional governance in North East England goes far back into the 20th century.
The Rise and Fall of the People’s Parties: A History of Democracy in Western Europe Since 1918
In This Review In This Review The Rise and Fall of the People’s Parties: A History of Democracy in Western Europe Since 1918 Contemporary threats to democracies from populist far-right parties, this book argues, are simply the effects of a deeper problem: the decline of the mass centrist parties of the center-right and center-left.
Financialization and Local Statecraft
In This Review In This Review Financialization and Local Statecraft On average, cities and towns account for over 20 percent of public spending in developed countries. In most places, much of the ordinary person’s quality of life depends on investments in schools, police, fire departments, health care, and other services, as well as roads, public spaces, and other local infrastructure.
Book Review: "Fixing France" by Nabila Ramdani
In This Review In This Review Fixing France: How to Repair a Broken Republic Ramdani, a French journalist who specializes in explaining her country to Anglo-Saxons, offers a lurid litany of well-known complaints about how the contemporary reality fails to match the country’s revolutionary ideals of “liberty, equality, and fraternity.” French politics has become an elitist preserve of white men from the best schools. French economy and society are unequal and self-dealing.
Crying wolf or creaking system?
By Andy Pike | 19 December 2023 As 2023 draws to a close, local government in England again finds itself in a financially vulnerable position. Subject to fiscal pressures, risks and uncertainties, local political leaders and officers continue to work through the contradictions of the highly centralised and creaking funding system.
Fixing a broken PWLB
When Government-appointed commissioners arrive to take up the financial and policy reins at councils who have issued section 114 (s114)notices of, effectively, insolvency, it is worth scrutinising the spreadsheets published by the Public Works Loan Board (PWLB) sitting quietly and unaccountably in the depths of the debt management office of the Treasury. The PWLB’s primary purpose has always remained to provide long-term affordable financing to councils for capital investment projects.
Councils’ last throw of the dice
The crisis in local council finances is coming to a head. A growing number of local council leaders are warning of funding gaps across England – from Hastings to Kirklees, Derby to Kent. More than a decade on from the UK Government’s introduction of austerity and its declared ambition for local government financial self-sufficiency, local councils continue to struggle with balancing their budgets.
Levelling Up Left Behind Places
1st Edition Copyright Year 2022 Levelling Up Left Behind Places: The Scale and Nature of the Economic and Policy Challenge ISBN | Quantity: Shopping Cart Summary Items: Routledge & CRC Press eBooks are available through VitalSource. The free VitalSource Bookshelf® application allows you to access to your eBooks whenever and wherever you choose.
Levelling up Left Behind Places
This book aims to understand the predicaments of ‘left behind places’ and the scale of the policy challenge of ‘levelling up’ their economic prosperity. Drawing out lessons of wider international significance, it examines how places (cities, towns and localities) have grown apart over recent decades amidst deindustrialisation, post-industrial transition and the disruptive shocks of the global financial crisis and COVID-19 pandemic.
Levelling Up?
Left behind there is now wide agreement that the problems of so-called ‘left-behind’ places have been accumulating for decades, if not generations. Cycles of local, urban and regional regeneration policy can be traced back almost a century through the May and coalition governments, New Labour, Thatcher and beyond, but geographical inequalities in socioeconomic conditions remain wide and stubbornly entrenched. What has changed is the new political attention that they are receiving.
The economics of belonging: the hidden costs behind large cities
Rather than competing for the next big thing against stronger, larger urban economies, left-behind places would be better served by policies aimed at securing their foundational economy by John Tomaney and Andy Pike / September 19, 2019 / Leave a comment Though Manchester is often used as a successful case study for the Northern Powerhouse brand, much of the growth has been in low productivity, low wage sectors.
In search of the skilled city: Skills and the occupational evolution of British cities
Autor, D (2015) Why are there still so many jobs? The history and future of workplace automation. The Journal of Economic Perspectives 29(3): 3–30. Google Scholar | Crossref | ISI Autor, D, Levy, F, Murnane, R (2003) The skill content of recent technological change: An empirical exploration. Quarterly Journal of Economics 118(4): 1270–1333. Google Scholar | Crossref Bacolod, M, Blum, B, Strange, W (2009) Skills in the city. Journal of Urban Economics 65: 136–153.
‘Deal or no deal?’ Governing urban infrastructure funding and financing in the UK City Deals
Aalbers, M (2015) The potential of financialization. Dialogues in Human Geography 5(2): 214–219. Google Scholar | SAGE Journals | ISI Ahrend, R, Farchy, E, Kaplanis, I. (2014) What makes cities more productive? Evidence on the role of urban governance from five OECD countries. OECD Regional Development Working Papers 2014/05. Paris: Organisation for Economic Cooperation and Development.
Funding, financing and governing urban infrastructures
Allen, J, Pryke, M (2013) Financialising household water: Thames Water, MEIF, and ‘ring-fenced’ politics. Cambridge Journal of Regions, Economy and Society 6(3): 419–439. Google Scholar | ISI Ashton, P, Doussard, M, Weber, R (2012) The financial engineering of infrastructure privatization: What are public assets worth to private investors? Journal of the American Planning Association 78(3): 300–312.
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