Angavai Swaminathan

Abstract The emergence of Candida auris as a pathogen required host adaptation and evasion of mammalian immunity, but the mechanisms are poorly understood. We discovered that C. auris uses nutrient sensing to tune its virulence traits and modulate immune activation in changing environments. In glucose-rich conditions (relevant to blood), C. auris suppresses its virulence traits and evades immune detection.

ArticleOnline nowOpen access Affiliations & Notes 1Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia 2Department of Biochemistry and Pharmacology, Bio21 Institute, University of Melbourne, Parkville, VIC, 3052, Australia 3Department of Biochemistry and Molecular Biology and the Development and Stem Cells Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800,...

Abstract Alternative polyadenylation has been linked to multiple developmental and disease transitions. The prevailing hypothesis being that differentiated cells use longer 3′ UTRs with expended regulatory capacity whereas proliferative cells use shorter 3′ UTRs. Here, we describe the gene expression and alternative polyadenylation profiles of human primary myoblasts over a time course of differentiation. Contrary to expectations, only minor changes in the 3′ end choice were observed.