Angela Rose Brannon on Muck Rack

Angela Rose Brannon

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Detection of MEN1 resistance mutations in cell-free DNA from acute leukemia patients treated with menin inhibitors

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By Neerav Shukla, Karmelina Charalambous, Shanita Li, Kaitlyn H. Ko, Ruchi Patel, Mark D. Ewalt, Maria Luisa Sulis, William Carroll Verified, Maria E. Arcila, Neeman Mohibullah, Michael Berger, Ross Levine, Eytan M. Stein, Ronak Shah, Sheng Cai, Hilary Casanova, Eric Buehler, Cassidy Cobbs, Angela Rose Brannon
| Nature Verified
Dear Editor, Menin inhibitors have emerged as a targeted therapeutic strategy for patients with acute leukemias driven by KMT2A gene rearrangements (KMT2Ar) and NPM1 mutations, where aberrant menin-KMT2A interactions sustain HOX-MEIS1-dependent transcriptional programs that are critical for leukemogenesis [1,2,3,4]. Positive early-phase studies led to regulatory approval of both revumenib and ziftomenib for these leukemia subtypes [5, 6].
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