Anjali Bisaria

Introduction Dilated cardiomyopathy (DCM) is a common type of myocardial disorder characterized by a dilated left ventricle and impaired systolic function. It is also associated with approximately half of the heart-failure cases in the United States. Among dozens of genes contributing to DCM, titin-truncating variants (TTNtv) constitute approximately 25% of familial cases and 18% of sporadic cases ( Roberts et al., 2015 Roberts A.M. Ware J.S. Herman D.S. Schafer S. Baksi J.

Actin cortex controls cell migration Cell migration is mainly controlled by local actin polymerization–driven membrane protrusion. However, a second structural mechanism might also regulate membrane protrusions and directed migration: changes in the density of the attachment between the plasma membrane and the underlying F-actin cortex, a parameter related to membrane tension. Many types of attachment and signaling mechanisms are known to alter the density of membrane-proximal cortical actin.

Research Article View ORCID ProfileAnjali Bisaria1,*, View ORCID ProfileArnold Hayer1,†, View ORCID ProfileDamien Garbett1, View ORCID ProfileDaniel Cohen2,‡, View ORCID ProfileTobias Meyer1,3,* 1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA. 2Department of Biology, Stanford University, Stanford, CA, USA. 3Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA. ↵*Corresponding author.