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As seen in: Stem Cell Reports
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Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery

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By South San Francisco, Anjali Bisaria, Guanyi Huang, Research Biomics
| Stem Cell Reports Verified
Introduction Dilated cardiomyopathy (DCM) is a common type of myocardial disorder characterized by a dilated left ventricle and impaired systolic function. It is also associated with approximately half of the heart-failure cases in the United States. Among dozens of genes contributing to DCM, titin-truncating variants (TTNtv) constitute approximately 25% of familial cases and 18% of sporadic cases ( Roberts et al., 2015 Roberts A.M. Ware J.S. Herman D.S. Schafer S. Baksi J.
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