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Articles by Anjon Audhya
Author Correction: In situ cryo-ET defines the ultrastructure of ER exit sites in human cells
Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-026-01964-2, published online 20 May 2026. The authors wish to correct the article to acknowledge a relevant recent article by Nair et al.1, which is now cited in the Discussion. The HTML and PDF versions of the article have now been corrected.
In situ cryo-ET defines the ultrastructure of ER exit sites in human cells
Abstract Trafficking of secretory proteins from the endoplasmic reticulum (ER) to the Golgi apparatus comprises the first, essential steps towards the appropriate localization of 30% of eukaryotic proteins. Coat protein complexes COPII and COPI are involved in the forward and retrograde transport of cargo and cargo receptors between the ER and the Golgi, respectively.
Mad1 facilitates α5 integrin trafficking from the Golgi to promote abscission during cytokinesis
Abstract Mad1 is an essential component of the mitotic spindle assembly checkpoint. During interphase, Mad1 regulates the trafficking of α5 integrin from the Golgi to the plasma membrane. Here, we show that depletion of Mad1 or α5 integrin induces cytokinesis failure. Though the cytokinetic furrow ingresses with normal timing, it ultimately regresses, resulting in cytokinesis failure.
A privileged ER compartment for post-translational heteromeric assembly of an ion channel
Abstract Mechanisms underlying heterotypic subunit assembly of ion channels and other oligomeric assemblies are poorly understood. In the human heart, heteromeric assembly of two isoforms encoded by the human ether-a-go go related gene (hERG) is essential for the normal function of cardiac IKr in ventricular repolarization, with loss of hERG1b contributing to arrhythmias associated with long QT-syndrome.
Partnership between UW-Madison and GE paved way for promising new Wisconsin tech hub Original
For too long, the economic opportunity and growth of biotech has been clustered in a few cities on the coasts. That may be about to change. The U.S. Department of Commerce’s Economic Development Administration Tech Hub program recently announced that Wisconsin will receive a game-changing $49 million in federal funding to advance personalized medicine, enhance health care outcomes and drive economic development.
Toxoplasma gondii infection accelerates the progression of hereditary spastic paraplegia
Abstract The parasitic protozoa Toxoplasma gondii chronically infects the central nervous system of an estimated one-third of the human population. Infection is generally subclinical, but immunocompromised individuals can experience a variety of neurological symptoms. Meta-analyses of T. gondii seropositivity have suggested a correlation between T. gondii infection and neurologic disease. While mechanistic studies on the relationship between T.
Delineating the shape of COPII coated membrane bud
Abstract Curvature-generating proteins that direct membrane trafficking assemble on the surface of lipid bilayers to bud transport intermediates, which move protein and lipid cargoes from one cellular compartment to another. Our recent study on the COPII protein Sar1 showed that the inserted volume of the protein into the membrane determines the degree of membrane bending. However, it is unclear what controls the overall shape of the membrane bud once curvature induction has begun.
TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo
Smith M.A. Hoffman L.M. Beckerle M.C. LIM proteins in actin cytoskeleton mechanoresponse. Trends Cell Biol. 2014; 24: 575-583https://doi.org/10.1016/j.tcb.2014.04.009 Winkelman J.D. Anderson C.A. Suarez C. Kovar D.R. Gardel M.L. Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism. Proc. Natl. Acad. Sci. USA. 2020; 117: 25532-25542https://doi.org/10.1073/pnas.2004656117 Sun X. Phua D.Y.Z. Axiotakis Jr., L. Smith M.A. Blankman E. Gong R.
Protein-induced membrane curvature in coarse-grained simulations
Introduction Cell membranes adopt various shapes in different organelles, with striking examples that include the membranes of endoplasmic reticulum (ER), the Golgi apparatus, and mitochondria ( 1 Alberts B. Bray B. Watson J.D. et al. Molecular Biology of the Cell. , ). In addition, membrane shape is remodeled in various processes such as endocytosis, virus infection, cell division, and organelle biogenesis ( 3 Membrane curvature and mechanisms of dynamic cell membrane remodelling.
Molecular simulation of mechanical properties and membrane activities of the ESCRT-III complexes
Taraknath Mandal Wilson Lough Saverio E. Spagnolie Anjon Audhya Qiang Cui Qiang Cui Correspondence For correspondence, contact Affiliations Departments of Chemistry, Physics, and Biomedical Engineering, Boston University, Massachusetts-02215, USA Search for articles by this author Abstract The endosomal sorting complex required for transport (ESCRT) machinery carries out the membrane scission reactions that are required for many biological processes throughout cells.
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