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Anna Barile

As seen in: Nature, Wiley Online Library, The Journal of Biological Chemistry
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Articles

Evolution of prediabetes in an urban cohort of adults living in a Mediterranean area - Nutrition & Diabetes

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By Cristiana Randazzo, Anna Barile
| Nature Verified
Abstract Prediabetes (PD) precedes type 2 diabetes (T2D), it can be easily recognized by fasting plasma glucose concentrations (FPG) or HbA1c or 2 h post glucose load glycemia, thereby enabling prevention strategies. We investigated the progression of PD to T2D in the ABCD study (Alimentazione, Benessere Cardiovascolare e Diabete -ISRCTN15840340) that included a representative cohort of adult people living in the Mediterranean area of Palermo (Italy).
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The ubiquitous pyridoxal 5′‐phosphate‐binding protein is also an RNA‐binding protein

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By Claudio Graziani, Anna Barile, Alessia Parroni, Irene De Cecio
| Wiley Online Library Verified
1 INTRODUCTION Although many aspects of vitamin B6 metabolism have been elucidated, fundamental questions remain unanswered. Perhaps, the most interesting and challenging one concerns the so-called pyridoxal 5′-phosphate binding protein (PLP-BP).
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The Z isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target - Graziani - The FEBS Journal - Wiley Online Li

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By Claudio Graziani, Anna Barile, Lorenzo Antonelli, Annarita Fiorillo
| Wiley Online Library Verified
Conflict of interest The authors declare no conflict of interest. References 1 & (2003) A genomic overview of pyridoxal-phosphate-dependent enzymes. EMBO Rep 4, 850–854. 2, & (2011) Vitamin B(6) salvage enzymes: mechanism, structure and regulation. Biochim Biophys Acta 1814, 1597–1608. 3, & (2012) Biomedical aspects of pyridoxal 5′-phosphate availability. Front Biosci (Elite Ed) 4, 897–913. 4, , , , , & (2022) Glutamic oxaloacetic transaminase 1 as a potential target in human cancer.
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