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Anna Barkaway

As seen in: Cell Press
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Articles

Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage

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By Anna Barkaway, Loïc Rolas, Régis Joulia, Jennifer V. Bodkin
| Cell Press Verified
Highlights • Aged mice show high levels of neutrophil reverse transendothelial migration (rTEM) • Mast cells (MC) and MC-derived CXCL1 drive neutrophil rTEM in inflamed aged tissues • Intensified endothelial ACKR1-CXCL1 axis promotes neutrophil CXCR2 internalization • Aged lungs program rTEM neutrophils toward an activated and noxious phenotype Summary Aging is associated with dysregulated immune functions. Here, we investigated the impact of age on neutrophil diapedesis.
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