Anna Sanchez Avila on Muck Rack

Anna Sanchez Avila

As seen in: Nature, Wiley Online Library
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Articles

Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection

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By Rachel Hodgson, Wan-Ping Huang, Vedanth Kumar, Haiyan An, Mark Driver, Anna Sanchez Avila, Brittany Ellis, Emily Day, Jessica Rayment, Kyungmin Baeg, Andrew Strange, Tobias Moll, Gareth Wright, Joke van Vugt, Scott Allen, Nicolas Locker, Ianthe L. Pitout, Susan Fletcher, Patrick R. Onck, Olivier Duss, Johnathan Cooper-Knock, Tatyana A. Shelkovnikova, Ruaridh Lang, Emil G. P. Stender, Zhaklin P. Chalakova
| Nature Verified
Abstract The paraspeckle is a disease-relevant biomolecular condensate assembled from long non-coding RNA (lncRNA) NEAT1_2 ribonucleoprotein particles. Paraspeckle biogenesis is suppressed in normal tissues, yet it can be rapidly upregulated under stress.
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Persistent Desert Microbiota in the Southern European Sky

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By Joan Cáliz, Xavier Triadó-Margarit, Anna Sanchez Avila, Anna Ayguasanosa Àvila, Mateu Menéndez-Serra
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description emi70046-sup-0001-Supinfo.docxWord 2007 document , 15.1 KB Data S1.Supporting Information Figures. emi70046-sup-0002-Tables.xlsxExcel 2007 spreadsheet , 80.1 KB Data S2. Supporting Information Tables. References 2001. “A New Method for Non-Parametric Multivariate Analysis of Variance.” Austral Ecology 26: 32–46. , , , et al. 2023.
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Opto-controlled C9orf72 poly-PR forms anisotropic condensates causative of TDP-43 pathology in the nucleus

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By Rachel Hodgson, Jessica Rayment, Wan-Ping Huang, Anna Sanchez Avila
| biorxiv.org
Abstract Proteinaceous inclusions formed by C9orf72 derived dipeptide-repeat (DPR) proteins are a histopathological hallmark in ~50% of familial amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) cases. However DPR aggregation/inclusion formation could not be efficiently recapitulated in cell models for four out of five DPRs. In this study, using optogenetics, we achieved chemical-free poly-PR condensation/aggregation in cultured cells, with spatial and temporal control.
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