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Articles by Anna Wenger
Extensive and differential platinum chemotherapy mutagenesis in livers of children
Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Editor’s summary Pediatric cancers are now more treatable than they have ever been before, but the treatments come with their own risks. Survivors of pediatric cancer can experience multiple long-term health consequences, some of which are not fully understood.
Single cell transcriptional evolution of myeloid leukemia of Down syndrome
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Abstract Children with Down syndrome have a 150-fold increased risk of developing myeloid leukaemia (ML-DS). Unusually for a childhood leukaemia, ML-DS arises from a preleukaemic state, termed transient abnormal myelopoiesis (TAM), via a conserved sequence of mutations. Here, we examine the relationship between the genetic and transcriptional evolution of ML-DS from natural variation; a rich collection of primary patient samples and foetal tissues with a range of constitutional karyotypes.
By Mi K Trinh, Konstantin Schuschel, Hasan Issa, Rebecca Thomas, Conor Parks, Agnes Oszlanczi, Di Zhou, Lira Mamanova, Elena Prigmore, Angus Hodder, Anna Wenger, Nathaniel Anderson, Holly Whitfield Verified, Taryn D Treger, José Gonçalves-Dias, Karin Straathof, David H. O’Connor, Matthew Young Verified, Laura Jardine, Stuart Adams, Jan-Henning Klusmann, Jack Bartram, Sam Behjati, Toochi Ogbonnah, Emilia R. Robertson
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Nature
Verified
A non-canonical lymphoblast in refractory childhood T-cell leukaemia - Nature Communications
Abstract Refractory cancers may arise either through the acquisition of resistance mechanisms or represent distinct disease states. The origin of childhood T-cell acute lymphoblastic leukaemia (T-ALL) that does not respond to initial treatment, i.e. refractory disease, is unknown. Refractory T-ALL carries a poor prognosis and cannot be predicted at diagnosis. Here, we perform single cell mRNA sequencing of T-ALL from 58 children (84 samples) who did, or did not respond to initial treatment.
High resolution clonal architecture of hypomutated Wilms tumours - Nature Communications
Abstract A paradigm of childhood cancers is that they have a low mutation burden, with some ostensibly bearing fewer mutations than the normal tissues from which they derive. We set out to resolve this paradox by examining paediatric renal cancers with exceptionally few mutations using high resolution, high depth sequencing approaches.
Somatic development of Wilms tumour via normal kidneys in predisposed children
The authors have declared no competing interest. This study is part of The Little Princess Trust Knowledge Bank of Wilms Tumour funded by The Little Princess Trust. Additional funding was provided by the Wellcome Trust (personal fellowship to S.B., institutional grant to the Wellcome Sanger Institute; references 220540/Z/20/A and 223135/Z/21/Z), the Wenner-Gren Foundations (personal fellowship to A.W.) and the Pessoa de Araujo family (personal fellowship to A.H.).
Survey About the SAP BTP Command Line Interface (btp CLI) - Your Opinion Matters!
Dear users of the btp CLI, do you have 6 minutes to help us improve the btp CLI? Take our survey now! The btp CLI is the command line tool for account management on SAP BTP.
Best Practices for Editing and Creating Content for Read Access Logging Delivered by SAP - SAP Blogs
Tips for Creating and Editing RAL Content in a Client Other Than 000 Content for read access logging (RAL) is delivered as part of support packages or new releases, either directly as part of SAP NetWeaver (SAP_BASIS, SAP_ABA) or from solutions. As the delivery class of the RAL tables is Customizing (“C”), content delivered by support package is imported only into client 000.
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