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Annabrita Hemmes on Muck Rack

Annabrita Hemmes

As seen in: BioRxiv, JoVE- Journal of Visualized Experiments
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Articles

Fibroblast Activation Protein Defines an Aggressive, Immunosuppressive EMT-associated Tumor Subtype in Highly Inflamed Localized Clear Cell Renal Cell Carcinoma

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By Teijo Pellinen, Lassi Luomala, Kalle Mattila, Annabrita Hemmes
| BioRxiv
Abstract Clear cell renal cell carcinoma (ccRCC) is among the most immune-infiltrated cancers, where high inflammation correlates with poor clinical outcomes. While epithelial-to-mesenchymal transition (EMT), immunosuppression, and cancer-associated fibroblasts (CAFs) have been linked with poor prognosis in metastatic ccRCC, their relevance and interplay in localized disease remain uncertain.
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Fibroblast activation protein defines aggressive EMT-associated cancer cell state and prognosis in localized ccRCC

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By Teijo Pellinen, Lassi Luomala, Kalle Mattila, Annabrita Hemmes
| BioRxiv
Abstract Despite being highly vascularized and immune-rich, the prognostic impact of immune infiltration and tumor microenvironment heterogeneity in localized clear cell renal cell carcinoma (ccRCC) remains unclear. Using 33-marker immunofluorescence imaging, we analyzed spatial distributions in 1,728 tissue cores from 435 localized ccRCC cases. Higher CD45⁺ infiltration correlated with worse survival, establishing CD45⁺ density as a prognostic marker.
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SOX9 has distinct roles in the formation and progression of different non‐small cell lung cancer subtypes

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By Jie Bao, Katja Närhi, Ana Teodòsio, Annabrita Hemmes
| Wiley Online Library Verified
Original Paper Jie Bao, orcid.org/0000-0002-1993-7309 Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland Search for more papers by this author Katja Närhi, Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland GlaxoSmithKline, Espoo, Finland Search for more papers by this author Ana Teodòsio, MRC Toxicology Unit, University of Cambridge, Cambridge, UK Search for more papers by this author Annabrita Hemmes,...
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