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Anne Chong Lab

As seen in: PLOS Biology, Cell Press
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Articles

Impact of non-sugar sweeteners on metabolism beyond sweet taste perception

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By Herbert Herzog, Anne Chong Lab
| Cell Press Verified
References 1. Rhee, E.J. The influence of obesity and metabolic health on vascular health Endocrinol. Metab. (Seoul). 2022; 37:1-8 2. GBD 2015 Obesity Collaborators ... Health effects of overweight and obesity in 195 countries over 25 years N. Engl. J. Med. 2017; 377:13-27 3. Pati, S. ... Obesity and cancer: a current overview of epidemiology, pathogenesis, outcomes, and management Cancers (Basel). 2023; 15:485 4. Racette, S.B. ...
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CRISPR activation screens: navigating technologies and applications

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By Anne Chong Lab, Matthew Waller, Cesar L. Moreno, César Moreno, Teleri Clark
| Cell Press Verified
Highlights Clustered regularly interspaced short palindromic repeats (CRISPR) activation (CRISPRa) technology allows pooled or targeted upregulation of gene expression. This new technical capacity helps to identify genes that, when upregulated, modify cell physiology and/or disease progression. Various CRISPR activation strategies have been described, with single and combinatorial activator domains enhancing gene activation efficiency.
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Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs

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By Anne Chong Lab, Matthew Waller, Cesar L. Moreno, César Moreno, Alexander Cole
| PLOS Biology Verified
Loading metrics Open Access Peer-reviewed Research Article Abstract Although ACE2 is the primary receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to SARS-CoV-2 spike protein has not been described. Here, we use whole-genome CRISPR activation to identify host factors controlling cellular interactions with SARS-CoV-2.
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