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Anne Doye

As seen in: Nature
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Articles by Anne Doye

Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization

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By Chloé Delaby, Maxence Bourgoin, Paul Chaintreuil, Cecile Favreau, Adele Rivault, Juba Bennour, Nathalie Droin, Jean-Francois Peyron, Johanna Chiche, Els Verhoeyen, Anne Doye, Laurent Boyer, Alexandre Gallerand, Stoyan Ivanov, Thomas Cluzeau, Michael Loschi, Patrick Auberger, Guillaume Robert Verified, Arnaud Jacquel, Emeline Kerreneur, Morgane Fajolles, Sonia Boulakirba, Amaury Aouad
| Nature Verified
Abstract Anti-inflammatory monocyte-derived macrophages are essential to maintain tissue homeostasis but can also contribute to disease progression, notably in cancer and fibrosis. Deciphering the signaling pathways that govern their generation could therefore unlock new therapeutic opportunities. Here we uncover a previously unrecognized, non-apoptotic function of caspase-8 in driving both monocyte-to-macrophage differentiation and anti-inflammatory macrophages polarization.
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Bacterial toxin sensing induces transient inflammasome-dependent innate immune memory that improves survival during sepsis

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By Ludovic Batistic, Els Verhoeyen, Grégory Michel, Patrick Munro, Anne Doye, Alexandre Gallerand, Stoyan Ivanov, Dorota Czerucka, Orane Visvikis, Bénédicte F. Py, Jessica Quintin, Laurent Boyer, Cédric Torre, Valentine Marion, Zakaryia Caillot, Margot Saissi, Océane Dufies, Céline Loubatier, Paul Chaintreuil
| Nature Verified
Abstract Adaptive immune memory generated by bacterial toxin vaccination is well established, but whether bacterial toxins can also induce innate immune memory, or trained immunity (TI), remains unclear. Here, we show that bacterial toxins elicit TI through NLRP3 inflammasome activation both in vitro and in vivo in mice, and that this response is conserved in primary human macrophages.
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Unoc 2025. Formation de à la course au large, rapprochements universitaires... On connaît déjà les suites locales du Sommet des océans

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By Anne Doye, Magali Roubaud-Soutrelle
| Franceinfo: Verified
Le skipper Jean-Pierre Dick pour former de futurs champions de la course au large, une association internationale pour accueillir les meilleurs apnéistes du monde avec Guillaume Nery, et un réseau d’universités marines du monde entier pour partager les recherches et les informations, à Nice, des initiatives pour apprendre et profiter de la mer glissent dans le sillage du sommet des océans, l'Unoc.
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Correction: Interaction of Saccharomyces boulardii with Salmonella enterica Serovar Typhimurium Protects Mice and Modifies T84 Cell Response to the Infection

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By Guillaume Dalmasso, Flaviano S. Martins, Anne Doye, Emmanuel Lemichez
| PLOS
Loading metrics Flaviano S. Martins, Guillaume Dalmasso, Rosa M. E. Arantes, Anne Doye, Emmanuel Lemichez, Patricia Lagadec, Veronique Imbert, Jean-François Peyron, Patrick Rampal, Jacques R. Nicoli, Dorota Czerucka Flaviano S. Martins, Guillaume Dalmasso, Rosa M. E. Arantes, Anne Doye, Emmanuel Lemichez, Patricia Lagadec, Veronique Imbert, Jean-François Peyron, Patrick Rampal, Jacques R.
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