Annelise E. Barron
Palo Alto
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Human cathelicidin peptide LL-37 compacts nucleic acids and alters neutrophil extracellular trap structure
Abstract The human cathelicidin host defense peptide LL-37 is expressed by many cell types, including neutrophils, macrophages, and epithelial cells, and forms complexes with nucleic acids that can have either beneficial or detrimental health effects. We suggest that these differential impacts are directly connected to the extent of nucleic acid binding by LL-37.
The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease
Aβ β-amyloid AD Alzheimer's disease ApoE Apolipoprotein E BBB blood–brain barrier Ca Candida albicans HCMV human cytomegalovirus HSV-1 herpes simplex virus 1 Pg Porphyromonas gingivalis Introduction In this review, we will discuss a novel hypothesis that certain chronic, undiagnosed, and typically unperceived bacterial/viral coinfections can trigger the pathogenesis of Alzheimer's disease (AD) (Fig. 1).
Time-resolved phenotyping at subcellular resolution reveals shared principles and key trade-offs across antimicrobial peptide activities
Abstract Cationic antimicrobial peptides are a large family of host defense molecules with diverse sequences and structures. Here, we present a computational and experimental pipeline for quantifying the membrane-permeabilizing effects, as well as the intracellular impacts on ribosome and DNA organization, of cationic peptides in growing Escherichia coli cells at high temporal and subcellular resolution.
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