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Articles by Anni Li
A hybrid system enables plasmid copy number control in yeast
Abstract Synthetic biology demands plasmid with tunable copy numbers. While dynamic plasmid copy number (PCN) regulation has been engineered in prokaryotes, a parallel capability remains unavailable in eukaryotic systems. Here, we develop a programmable PCN platform for S. cerevisiae based on the endogenous 2μ plasmid. The p2μ-Cir0 system achieves up to 20 copies per cell with enhanced homogeneity and stability, supporting 60-fold higher expression than chromosomal integration.
Electrical Engineering and Systems Science > Systems and Control
[Submitted on 23 Feb 2026 ( v1 ), last revised 29 Oct 2026 (this version, v2)] Title:Robust Taylor-Lagrange Control for Safety-Critical Systems with Guaranteed Feasibility View a PDF of the paper titled Robust Taylor-Lagrange Control for Safety-Critical Systems with Guaranteed Feasibility, by Wei Xiao and Christos Cassandras and Anni Li View PDF HTML (experimental) Abstract:The Control Barrier Function (CBF) method has been widely adopted in solving safety-critical control problems.
Integrating graph learning and meta-learning to enhance PET hydrolase activity at elevated temperatures
Keywords polyethylene terephthalate machine learning enzymatic depolymerization MD simulation dual-enzyme system Introduction Among the petroleum-based plastics, polyethylene terephthalate (PET) is one of the most widely produced synthetic polymers, with a global manufacturing capacity exceeding 30 million tons annually. The extensive use of PET in packaging and textiles, combined with its recalcitrant nature, has led to pressing challenges in plastic waste management and environmental pollution.
Recent Advances in Electrochemical Benzylic C(sp3)−H Functionalization
Direct benzylic C(sp3)–H functionalization has emerged as a topic in organic synthesis due to its critic role in constructing complex and valuable molecules. Among the various methodologies employed, electroorganic synthesis has garnered considerable attention in diversifying benzylic C(sp3)–H functionalization. In recent years, substantial progress has been made in electrochemical benzylic C(sp3)–H functionalization.
Modifiable Risk Factors and Attributable Burden of Cardiac Arrest: An Exposome-wide and Mendelian Randomization Analysis
School of Public Health, Key Laboratory of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, China Publication History: Received September 12, 2024; Accepted February 18, 2025; Published online April 28, 2025 DOI: 10.1016/j.cjca.2025.02.027 External LinkAlso available on ScienceDirect External Link Copyright: © 2025 Canadian Cardiovascular Society. Published by Elsevier Inc.
Ancestral Sequence Reconstruction and Comprehensive Computational Simulations Unmask an Efficient PET Hydrolase with the Wobbled Catalytic Triad
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Cover Feature: Empowering Protein Engineering through Recombination of Beneficial Substitutions (Chem. Eur. J. 16/2024)
Xinyue Wang School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, No. 2 Xuelin Road, Nanjing, 210097 China These authors contributed equally Search for more papers by this author
Empowering Protein Engineering Through Recombination of Beneficial Substitutions
Directed evolution stands as a seminal technology for generating novel protein functionalities, a cornerstone in biocatalysis, metabolic engineering, and synthetic biology.
Cyclization of Azobenzenes Via Electrochemical Oxidation Induced Benzylic Radical Generation
An electrochemical oxidation-induced cyclization of ortho-alkyl-substituted azobenzenes has been developed. The direct electrochemical benzylic C–H functionalization with respect to azobenzenes could proceed in the absence of any catalyst or external chemical oxidant to afford a number of 2H-indazole derivatives in moderate to good yields. This protocol enables the reuse of the byproduct to the same 2H-indazoles, thus significantly reducing pollution discharge in synthetic chemistry.
Electrochemical oxidation-induced benzylic C(sp3)-H functionalization towards atom-economic synthesis of oxazole heterocycles
Electrochemical oxidation-induced benzylic C(sp3)–H functionalization towards atom-economic synthesis of oxazole heterocycles Na Yang, Anni Li, Hui Gao, Li-Mei Liao, Yu-Ping Yang, Pei-Long Wang and Hongji Li Abstract A unique electrochemical four-component reaction of terminal alkynes, (thio)xanthenes, acetonitrile and water has been established in the absence of any catalyst or external oxidant.
[2211.10295] Evaluating generative models in high energy physics
[Submitted on 18 Nov 2022 ( v1 ), last revised 21 Apr 2023 (this version, v2)] Title:Evaluating generative models in high energy physics Download a PDF of the paper titled Evaluating generative models in high energy physics, by Raghav Kansal and Anni Li and Javier Duarte and Nadezda Chernyavskaya and Maurizio Pierini and Breno Orzari and Thiago Tomei Download PDF Abstract: There has been a recent explosion in research into machine-learning-based generative modeling to tackle computational...
Evaluating generative models in high energy physics
Abstract There has been a recent explosion in research into machine-learning-based generative modeling to tackle computational challenges for simulations in high energy physics (HEP). In order to use such alternative simulators in practice, we need well-defined metrics to compare different generative models and evaluate their discrepancy from the true distributions.
Evolving Robust and Interpretable Enzymes for the Bioethanol Industry
Graphical Abstract Enzymes are at the core of biotransformation in first- and second-generation bioethanol production processes. By integrating the transferable protein evolution strategy InSiReP 2.0 (In Silico guided Recombination Process), the model cellulase PvCel5A was evolved to overcome the remaining challenge of low ethanol tolerance and thermal stability, which hindered the further improvement of biomass transformation and bioethanol yield prior to this study.
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