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Anqi Li

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Articles

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis

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By Wenjie Wang, YUAN ZHANG, Fenglian He, Li Sun, Huiyu Li, Rongchen Liu, Ling Zhang, Anqi Li, Mei Feng, Yuxuan Dong, Xiaoxuan Lu, Xiaojin Wang, Yuan Si, Yejun Wu, Mengmeng Zhao, Dafu Zhu, Jian Chen, JING CHEN, Ming-Wei Wang, Di Zhu, Likun Gong, Bingshun Wang, Guanglin Zhong, Zhuyi Xi
| Nature Verified
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibroblast function thus represents an effective therapeutic approach for treating IPF. Here, we identify B-cell lymphoma 9 (BCL9) as a key upstream regulator implicated in IPF pathogenesis.
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3D-printed chiral luminous materials

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By Anqi Li, Shanshan Zhao, Mingjiang Zhang, Jing Lin, Yanji Huang, Zeyi Li, Guangen Li, Zhi Tong, Taotao Zhuang
| Nature Verified
Abstract 3D printing allows creation of complex, precise chiral luminous materials—with dynamically switchable, circularly polarized light emissions—enabling spatial control over light-matter interactions for advanced optical applications. However, high-performance, additively manufactured chiral materials have yet to be realized, because preservation of chiral molecular alignment and interlayer structural integrity during rapid curing or processing remains challenging.
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Intestinal stem cells count self-renewal divisions to switch multipotency

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By Dong Tong, Anqi Li, Quanquan Jiang, Xiaozhao Liu, Ximiao HE, Jiejunyi Liang, Yunyun Han, Zheng Guo, Qili Yuan
| Nature Verified
Abstract Multipotent stem cells maintain tissue homeostasis by producing distinct daughter cell types in defined proportions1,2, but how they coordinate type-specific ratios during repeated divisions remains unknown. Drosophila intestinal stem cells (ISCs) switch between producing enteroendocrine cells (EECs) and enterocytes (ECs)3,4, yet maintain a constant EEC:EC ratio despite rapid tissue turnover5,6,7.
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