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Articles by Anran Chen
Interindividual variability in gut microbiome mediates the efficacy of resistant starch on MASLD
Keywords metabolic dysfunction-associated steatotic liver disease gut microbiota resistant starch treatment effect heterogeneity prebiotics precision medicine multi-omics Bifidobacterium pseudocatenulatum Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD), previously recognized as non-alcoholic fatty liver disease (NAFLD), is gaining increasing attention as a global health crisis.1 It encompasses a spectrum ranging from simple steatosis to metabolic...
NF1-depleted ER+ breast cancers are differentially sensitive to CDK4/6 inhibitors
Editor’s summary Neurofibromin (NF1) is an estrogen receptor (ER) transcriptional corepressor, and low expression is associated with endocrine therapy resistance in ER+/human epidermal growth factor receptor 2 negative (HER2−) breast cancer. To investigate this, Zheng et al. evaluated the potential sensitivity of these patients to CDK4/6 inhibitors.
PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
Keywords Humans, Breast Neoplasms, Female, Cyclin-Dependent Kinase 4, Animals, Mice, Cyclin-Dependent Kinase 6, Drug Resistance, Neoplasm, Protein Kinase Inhibitors, Xenograft Model Antitumor Assays, Cell Line, Tumor, Biomarkers, Tumor, Piperazines, Pyridines, Receptors, Estrogen, Gemcitabine, Protein-Tyrosine Kinases, Apoptosis Abstract Endocrine therapies (ET) with cyclin-dependent kinase 4/6 (CDK4/6) inhibition are the standard treatment for estrogen receptor-α-positive (ER+) breast...
Dual Single-Atom Sites Coupled with Graphene-Encapsulated Core-Shell Fe-Cu Nanoalloy for Boosting Oxygen Reduction Reaction
Dual Single-Atom Sites Coupled with Graphene-Encapsulated Core-Shell Fe-Cu Nanoalloy for Boosting Oxygen Reduction Reaction Replacing platinum-based electrocatalysts with iron single-atom catalysts (Fe-N4-C) for the oxygen reduction reaction (ORR) remains challenging due to the symmetric electronic structure of atomically dispersed Fe-N4 sites and sluggish kinetics.
Densely Accessible Fe/Co-Nx Dual-atom Sites Coupled Core-shell Co3Fe7@C as an Efficient Bifunctional Oxygen Electrocatalyst for Rechargeable Zinc-air Batteries
Densely Accessible Fe/Co-Nx Dual-atom Sites Coupled Core-shell Co3Fe7@C as an Efficient Bifunctional Oxygen Electrocatalyst for Rechargeable Zinc-air Batteries The urgent demand for stable and highly efficient bifunctional electrocatalysts for the oxygen reduction/evolution reactions (ORR/OER) is pivotal in advancing energy conversion and storage technologies.
Constructing Amorphous‐Crystalline Interfacial Bifunctional Site Island‐Sea Synergy by Morphology Engineering Boosts Alkaline Seawater Hydrogen Evolution
1 Introduction The energy crisis and environmental challenges rooted in the widespread use of fossil fuels compel us to explore sustainable and clean energy.[1] As an ideal clean fuel and energy carrier, hydrogen has recently sparked a new wave of research due to its exceptionally high energy density and zero carbon emissions.[2] Electrochemical water splitting has emerged as the most promising method for high-purity hydrogen production, given its relatively high energy exchange efficiency...
Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function
1 INTRODUCTION The sensation of pain begins with the transduction of a stimulus in the periphery nerves and is converted to electrical signals that travel to the central nervous system.
MOF-on-MOF-Derived Ultrafine Fe2P-Co2P Heterostructures for High-Efficiency and Durable Anion Exchange Membrane Water Electrolyzers
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Nano 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Dense Crystalline/Amorphous Phosphides/Oxides Interfacial Sites for Enhanced Industrial-Level Large Current Density Seawater Oxidation
Designing high-efficiency and low-cost catalysts with high current densities for the oxygen evolution reaction (OER) is critical for commercial seawater electrolysis. Here, we present a heterophase synthetic strategy for constructing an electrocatalyst with dense heterogeneous interfacial sites among crystalline Ni2P, Fe2P, CeO2, and amorphous NiFeCe oxides on nickel foam (NF).
How Does Buddhist Contemplative Space Facilitate the Practice of Mindfulness?
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Rational Design of Hierarchical, Porous, Co‐Supported, N‐Doped Carbon Architectures as Electrocatalyst for Oxygen Reduction
Full Paper Mengfei Qiao Key Laboratory of Chemistry of Plant Resources in Arid Regions, State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Science, Urumqi, 830011 P. R. China University of Chinese Academy of Sciences, Beijing, 100049 P. R. China These authors contributed equally to this work.
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