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Condensin and topoisomerases cooperate to relieve topological stress at stalled replication forks
Abstract Resolving complex topological structures at replication forks is essential for faithful DNA replication, yet the underlying mechanisms remain poorly understood. Evidence from diverse eukaryotes suggests that condensin – best known for driving chromosome condensation in mitosis – may also operate during S phase to alleviate torsional stress in cooperation with topoisomerases.
RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart
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A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization
Ahmed S. Brickner D.G. Light W.H. Cajigas I. McDonough M. Froyshteter A.B. Volpe T. Brickner J.H. DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery. Nat. Cell Biol. 2010; 12: 111-118 Akhtar A. Gasser S.M. The nuclear envelope and transcriptional control. Nat. Rev. Genet. 2007; 8: 507-517 Bagchi D.N. Iyer V.R. The Determinants of Directionality in Transcriptional Initiation. Trends Genet. 2016; 32: 322-333 Biernacka A. Zhu Y. Skrzypczak M. Forey R. Pardo B. Grzelak M. Nde J.
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