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Anveshi G. Guha on Muck Rack

Anveshi G. Guha

As seen in: Cell Reports
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Articles

Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption

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By Keisha Cawley, of Arkansas, Nancy Cecile Bustamante-Gomez, Anveshi G. Guha
| Cell Reports Verified
Highlights • Deletion of Tnfrsf11b from B cells or osteocytes has minimal effects on bone mass • Deletion of Tnfrsf11b from osteoblasts increases resorption and reduces bone mass • Circulating osteoprotegerin levels do not correlate with changes in bone resorption • Osteoblasts directly suppress osteoclast production by producing osteoprotegerin Summary Osteoprotegerin (OPG) inhibits the ability of receptor activator of nuclear factor κB (NF-κB) ligand (RANKL) to stimulate the...
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