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Articles by Application Scientist
Metabolic flux: the dynamic flow of biochemical reactions
Introduction to metabolic flux analysis Metabolism is universal to all cells and involves thousands of metabolites distributed through interconnected pathways.1-4 This has important consequences for the viability of a cell.
Mitochondrial metabolism and cellular function
Introduction Mitochondria are often referred to as the powerhouses of the cell since they produce most of the adenosine triphosphate (ATP) that serves as the primary energy source to support cellular function. However, the contribution of mitochondrial metabolism to cellular function is not limited to the production of ATP. Mitochondrial metabolism is essential on many fronts including crucial anabolic and catabolic processes that provide diverse molecules and energy sources to support life.
Understanding metabolism in cancer
The tumor microenvironment is a dynamic and complex ecosystem that plays a pivotal role in cancer development, progression, and therapeutic response. Composed of a diverse array of cell types — including cancer cells, immune cells, stromal cells, and vascular cells — the tumor microenvironment forms a supportive network that not only nurtures tumor growth but also shapes the metabolic fate of cancer cells (Fig.
Phototrophic Cultivation Of Chlorella vulgaris In The BioLector XT Microbioreactor
By Noud Drummen, Application Scientist, Beckman Coulter Life Sciences This content is brought to you by Beckman Coulter, a Danaher Operating Company. Microalgae have emerged as a cornerstone for sustainable bioprocessing, offering solutions for biofuel production, carbon capture, and the production of high-value compounds. This resource explores advanced strategies for phototrophic cultivation of Chlorella vulgaris, a versatile species widely used in food, feed, and bioenergy applications.
Binding constants on a microplate reader
Introduction This blog is about binding constants (association, dissociation or equilibrium constants), how to measure them, and the crucial role they play in understanding molecular interactions. By definition, a binding constant quantifies the strength of the interaction between two molecules, such as a ligand and its binding partner, under equilibrium conditions.
Phototrophic Cultivation Of Chlorella vulgaris In The BioLector XT Microbioreactor Original
By Noud Drummen, Application Scientist, Beckman Coulter Life Sciences This content is brought to you by Beckman Coulter, a Danaher Operating Company. Microalgae have emerged as a cornerstone for sustainable bioprocessing, offering solutions for biofuel production, carbon capture, and the production of high-value compounds. This resource explores advanced strategies for phototrophic cultivation of Chlorella vulgaris, a versatile species widely used in food, feed, and bioenergy applications.
Accelerating Biopharma Development: A Greener & Faster Approach with A-TEEM® Spectroscopy for Monoclonal Antibodies and Peptides
Beginning: 12/04/25 Location: Online The biopharmaceutical industry faces increasing pressure to develop therapies faster, more efficiently, and with a smaller environmental footprint. To address these challenges, Process Analytical Technology (PAT) has become indispensable for enabling real-time monitoring, minimizing offline testing, and accelerating development timelines.
Monitoring Subvisible Particles in Biotherapeutics
By: Austin Daniels, PhD, Application Scientist, Yokogawa Fluid Imaging Technologies Subvisible Particles in Biotherapeutics Impact Product Quality and Safety Biotherapeutics continue to revolutionize how clinicians treat many human diseases. Protein therapies using molecules like peptides and monoclonal antibodies have become well established in the clinic.
Big pharma case study: alpha testing of a generic anti-AAV kit and comparison to in-house methods
Gene delivery via AAV vectors has emerged as a pivotal technology in the clinical treatment of human diseases. The non-pathogenic viruses transduce cells, leading to a long-term expression of clinically relevant transgenes.
Durability is more important than record-breaking solar cell efficiencies
The race for higher efficiencies in solar cells has captured the imagination of researchers, investors and the general public alike. Record-breaking efficiencies promise more energy from smaller and cheaper solar panels. In only 15 years, perovskite solar cells achieved high efficiencies over 25% — it took 37 years to achieve comparable efficiencies with popular crystalline silicon solar cells.
Label-free Quantitative Proteomics Analysis Advances Understanding of Biological Processes
In mass spectrometry-based proteomics, quantitation accuracy, sample throughput, and the long-term stability and reproducibility of the workflow are crucial for obtaining reliable results that advance biological insights. Accurately quantifying abundances of proteins of interest in complex samples is a prerequisite for developing suitable predictive models and testing them against experimental data sets.
LC Learning Series: Mastering the art of column choice
Having trouble separating compounds, and wondering what is the single most important parameter to change? Questions over characterizing high molecular weight compounds such as oligonucleotides? Tackle column selection like an expert by registering for the LC Learning Series, a free resource provided by Separation Science and PerkinElmer.
Cell therapy workflows: improving reproducibility and simplifying compliance efforts with batch centrifugation solutions
Wednesday May 31st 2023 08:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST Live30 webinars are thirty-minute presentations designed to update you on the latest innovations, applications, and data in a fast yet interactive format. Centrifuges are pillars of most biology applications. As cell therapy studies have been picking up pace, the role of centrifugation deserves a closer look.
Complete system for AAV production for clinical production: Part 1 Upstream
AAV manufacturing challenges have been extensively discussed for several years. With a limited biological understanding of recombinant vector production and the limited amount of time developers have to optimize, scale, and qualify their manufacturing process, flexible solutions that can adapt to several vectors, cell lines, or facilities are needed. Thermo Fisher Scientific has answered this need with systems, reagents, and equipment that meet the needs of this fast-moving industry.
Optimizing mRNA purification conditions by using a High Throughput Screening approach
Tuesday June 14th 2022 8:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST Live30 webinars are thirty minute presentations designed to update you on the latest innovations, applications and data in a fast yet interactive format. To support the development of mRNA-based therapies we have developed a platform chromatography solution for the purification of mRNA.
Complete system for AAV production for clinical production: Part 1 Upstream
AAV manufacturing challenges have been extensively discussed for several years. With a limited biological understanding of recombinant vector production and the limited amount of time developers have to optimize, scale, and qualify their manufacturing process, flexible solutions that can adapt to several vectors, cell lines, or facilities are needed. Thermo Fisher Scientific has answered this need with systems, reagents, and equipment that meet the needs of this fast-moving industry.
Optimizing mRNA purification conditions by using a Design of Experiments approach
Live30 webinars are thirty minute presentations designed to update you on the latest innovations, applications and data in a fast yet interactive format. To support the development of mRNA-based therapies we have developed a platform chromatography solution for the purification of mRNA. The POROS™ Oligo dT(25) affinity resin helps to address the selectivity and capacity requirements for the large-scale manufacturing of mRNA used in vaccine and gene therapy applications.
Applications of Terahertz Molecular Lasers
The terahertz spectral region falls between the microwave and infrared ranges, and it is one of the most promising regions of the electromagnetic spectrum. However, this region is currently underutilised in research and industry. There is no universal definition for what constitutes the terahertz band, but the frequency range of 0.1 to 10 THz (λ = 3 mm to 30 μm) is the most widely referenced.
Five Tricks for Troubleshooting Your LC Methods
1. Start by determining your key predictive sample set (KPSS). A good start can circumvent future troubleshooting. Understand the purpose of your method development first, and determine the fewest number of samples you will need to run, while including all necessary chemical components: PRIs, intermediates, real-time stability degradants, and so on. 2. Check solubility for all analytes, and consider pH and pKa for ionizable analytes.
CCI Testing Method Development For Vials Stored At -80C, Using Headspace Gas Ingress
By Allison Alix, Application Scientist, Lighthouse Instruments Sterile pharmaceutical products such as live viral vaccines, gene therapies, and products that contain active cells often require deep cold storage, either at -80°C or cryogenic temperatures (-196°C) to maintain stability and/or activity. These storage conditions pose a challenge to the packaging components; in particular to the sealing performance of the vial/rubber stopper combinations traditionally used to package these products.
Water Activity Measurements And Microbial Contamination In Pharmaceutical Products
By Allison Alix, Application Scientist, Lighthouse Instruments Non-sterile pharmaceutical products, including oral solid dosages (OSDs) such as tablets, capsules, and softgels, are subject to microbiological examination prior to release and during stability testing. USP <61> and USP <62> describe the methods for enumeration and specification of these microorganisms, respectively.
Water Activity Determination Of Oral Solid Dosage Products Using Frequency Modulation Spectroscopy
By Allison Alix, Application Scientist, Lighthouse Instruments Controlling water content in oral solid dosage (OSD) products, and dry pharmaceutical products in general, is essential to maintaining efficacy and safety. Water activity (Aw) is a measurement of the free or loosely bound water available to participate in unwanted chemical, physical, and biological reactions.
Effectiveness of UV Light-Emitting Diodes for Inactivating Biomolecules and Microorganisms
By Theresa Thompson, Ph.D., Application Scientist, Phoseon Technology Ultraviolet (UV) LED technology for curing is one of the market segments that has gained worldwide acceptance and continues to grow. But, there are many other industrial and life sciences applications throughout the UV spectrum that utilize UV LED technology. This article examines the effectiveness of UV LED for decontamination and disinfection applications.
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